Claude Opus 4.5, rare disease research & more (November 25, 2025)

Good morning,

AI earnings, government initiatives and new research breakthroughs are shaping today’s landscape. Between big tech’s chip dependence and fresh federal funding pushes, the ecosystem keeps accelerating in every direction. Plenty to dig into today.

Let's dig in👇

🤖 AI Models and Research

🧠 Anthropic unveils Claude Opus 4.5

Anthropic released Claude Opus 4.5 with upgraded reasoning and multimodal capabilities. Early testers report efficiency improvements in long form task execution. The release puts pressure on other frontier labs to keep pace with rapid iteration cycles.

🧬 Harvard researchers debut new rare disease model

Harvard Medical School introduced a new AI model to speed rare disease diagnosis significantly. The system could reduce multi year diagnosis journeys for thousands of patients. Medical AI continues expanding into high impact use cases that improve clinical outcomes.

🏛️ Trump signs executive order launching Genesis

Trump signed an executive order launching the Genesis mission to advance national level AI systems. Supporters say it positions federal agencies for a coordinated research jump. Critics see it as a new phase in global AI geopolitics.

🚀 Big Moves & Tech Earnings

📈 Nvidia jumps as AI chip demand keeps climbing

Nvidia shares rose today after analysts reported strong AI chip demand across Google and Meta. Investors saw the latest report as validation that hyperscalers are nowhere near slowing their GPU budgets. Nvidia’s long term trajectory remains tightly tied to AI infrastructure spending.

💹 Alibaba pops on cloud revenue acceleration

Alibaba shares climbed after announcing that AI boosted its cloud division’s growth significantly. The news signals China’s enterprise AI adoption is accelerating at scale. Global cloud competition continues tightening as more companies pour into generative AI.

🏢 Amazon expands AI partnerships with US agencies

Amazon announced a major AI investment into US federal agencies to modernize government systems. The move strengthens Amazon’s footprint across public sector digital infrastructure. It also intensifies the cloud giants competition for major federal contracts.

🛠️ Tools of the Day

→ Claude Opus 4.5 - Anthropic’s newest model update to Claude.
→ Nao 2 - Local model runner that handles quick experiments and lightweight inference.
→ Hatable - Fast table creator that turns messy data into clean structured output.

💬 Prompt of the Day

Write a three sentence summary comparing two new AI models from today’s news as if you are pitching them to a skeptical CTO.

⚡ Quick Hits

→ ChatGPT shopping adds smarter research flows for consumer buying decisions
→ OpenAI learned Cameo trademark forces unexpected naming change at OpenAI
→ Altman describes new AI device as calmer alternative to modern smartphones
→ Zaya1 AI uses AMD GPUs to reach key training milestone
→ A new benchmark tests chatbot safety and wellbeing protections

🧩 TLDR

Nvidia and Alibaba reported strong AI driven financial wins, the US government expanded its AI ambitions, and new frontier and medical models arrived with meaningful upgrades. Big tech, public sector and research labs all dropped major updates today. The acceleration continues from every side of the ecosystem.

Best,
David